'Oxidative Stress is the uncontrolled production of free radicals.
Oxidative stress is the primary cause of nerve diseases like Parkinson's and Alzheimer's
Oxidative stress accelerates aging.
Minimizing damage by providing antioxidants that can cross the blood-brain barrier is a good practice to begin as early in life as possible.
It is of paramount importance if preventing or delaying disease is sought.
Minimizing free radical production and neutralizing them with a library of antioxidants is the core of this anti-aging strategy.
Lipid peroxidation by free radicals is responsible for the deteriorating process that results in dysfunction. These illnesses include atheroschlerosis, arthritis, and cataracts. These attacks occur in the body, not the brain.
Oxidative stress in the brain is linked to neuronal degeneration, which ultimately leads to stroke, brain dysfunction and aging.
Preventing these attacks is one of the goals of smart drugs.
Highly metabolic tissues, brain and muscle, increase oxygen consumption which creates oxygen radicals. These free radicals are produced during oxgen use. Their removal is dependent on the body''s scavenging system. Augmenting this system is another goal of smart drugs.
Molecular debris and tissue damage accumulates with age.
Since the damage this damage causes is so fundamental to function there is no limit to its potential destructive force.
Oxidative stress can be minimized by a library of antioxidants and it follows that the conditions associated with aging, like atheroschlerosis, dementia, and arthritis can also be minimized.
The nootropic effect of a diet, rich in antioxidants and other micronutrients, is improved nerve transmissions.
And is due to is the quenching of free radicals before they can attack and upset transmissions.
The body''s antioxidant defense system deploys the enzymes superoxide dismutase, catalase and glutathione peroxidase.
They, along with Vitamins C and E work synergistically to neutralize free radicals.
There effectiveness in the brain becomes limited as damage progresses.
Therapeutic attention has been directed to two groups of agents.
One that functions in the role of free radical scavengers, the other augments those already present.
This includes retinoic acid (Vitamin A, beta-carotene), deprenyl or selegiline, a MAO-B inihibitor, gingko biloba, selenium, zinc and riboflavin.
A powerful group of compounds thought to fortify the body''s scavenging system.