Milk thistle refers to the dried fruit of the flowering plant, Silybum marianum.
Part of the daisy family, this herb is also called blessed thistle as well as wild artichoke.
Milk thistle grows in dry rocky soil.
Its seeds, fruit, and leaves are all used for medicinal purposes.
Milk thistle is described in Chinese pharmacopoeias as 'providing nourishment to restore liver function and balance or yin and yang'
Milk Thistle contains silymarin (the collective name for a group of three similarly structured flavonoid compounds, (silybin, silydianin, and silychristin).
This 'library' of compounds are important liver-protecting antioxidants.
Silymarin promotes the regeneration of injured hepatic cells and is used in the treatment of cirrhosis, hepatitis and fatty inflammation of the liver.
Disease like gout, cirrhosis, hepatitis, and diabetes may be minimized with Milk thistle.
It is also useful in the management of hangovers.
Silymarin is a very powerful antioxidant.
Silymarin increases glutathione and superoxide dismutase concentrations in liver cells (hepatocytes).
The increase in glutathione concentration increases the capacity of the liver to detoxify drugs, hormones, and other metabolites that it has responsibility for.
Silymarin is an inhibitor of lipoxygenase.
Lipoxygenase catalyzes a reaction required in the formation of leukotrienes.
Leukotrienes are essential to the inflammatory process so inhibition of their formation enhances liver function.
Inflammed livers accelerate disease,
Of particular interest to athletes, in addition to its potent protective effects, is the stimulation of protein synthesis and nucleic acid metabolism,
Combined with its regulatory role in glycogenesis, standardized, Milk Thiste extracts are a valuable ally for athletes who drink alcohol or take recreational drugs
Milk thistle is the dried fruit and is described in Chinese pharmacopoeias as providing nourishment to restore liver functions and balance yin and yang. Silymarin, the active agent promotes the regeneration of injured hepatic cells. It is used in the treatment of cirrhosis, hepatitis and fatty inflammation of the liver. Also called wild artichoke.
Milk Thistle contains silymarin (the collective name for a group of three similarly structured flavonoid compounds, (silybin, silydianin, and silychristin), which are important liver-protecting substances.
Silymarin is a very powerful antioxidant and increases glutathione and superoxide dismutase concentrations in liver cells (hepatocytes). The increase in glutathione concentration increases the capacity of the liver to detoxify drugs, hormones, and other metabolites that it has responsibility for.
Silymarin is an inhibitor of lipoxygenase. Lipoxygenase catalyzes a reaction required in the formation of leukotrienes. Leukotriene formation is involved in the inflammatory process and its inhibition further enhances liver function.
Picrorhiza (kutki) is found in the Himalayan region and has been in use in Ayurveda for centuries as a cure for jaundice, liver disease, indigestion and related conditions.
Since the liver is responsible for cholesterol removal, any beneficial protective effect offered to liver cells may also result in an improved blood lipid profile.
Chemistry and Pharmacology
Picroliv is a standardized mixture of iridoid glucosides containing 4% kutkin. Kutkin, the active component is a mixture of picrosides and kutkosides.
Extracts of pivrorhiza kurroa have shown a hepatoprotective ability due to glutathione stimulation and superoxide dismutase (SOD) activity. The overall reactivity is improved through microsomal detoxification and free radical neutralization of the superoxide anion, thereby reducing the amount of lipid peroxidation products. produced. The accumulation of damaged products cause disease. Their reduction prevents it.
A reduction of triglycerides and cholesterol as well as inhibiting the inflammatory system is the purported benefits of picroliv. This occurs by minimizing the migration of white blood cells to areas of inflammation and stabilizing mast cells. The phytonutrients contained in Picroliv act via beta-adrenergic blockade, which accounts for its anti-inflammatory activity.
In addition to its role in inflammation, hepatoprotection, and antioxidant activity, extracts of P. kurroa promotes the synthesis o