Milk Thistle

Milk thistle refers to the dried fruit of the flowering plant, Silybum marianum.

Part of the daisy family, this herb is also called blessed thistle as well as wild artichoke.

Milk thistle grows in dry rocky soil. Its seeds, fruit, and leaves are all used for medicinal purposes.

Milk thistle is described in Chinese pharmacopoeias as providing nourishment to restore liver function and balance yin and yang.

Milk Thistle contains silymarin (the collective name for a group of three flavonoid compounds, silybin, silydianin, and silychristin).

This library of compounds are important liver-protecting antioxidants..

Silymarin promotes the regeneration of injured hepatic cells and is used in the treatment of cirrhosis, hepatitis and fatty inflammation of the liver.

Disease like gout, cirrhosis, hepatitis, and diabetes may be minimized with Milk thistle.

It is also useful in the management of hangovers.

Silymarin is a very powerful antioxidant and increases glutathione and superoxide dismutase concentrations in liver cells (hepatocytes).

The increase in glutathione concentration increases the capacity of the liver to detoxify drugs, hormones, and other metabolizes that it has responsibility for.

Silymarin is an inhibitor of lipoxygenase. Lipoxygenase catalyzes a reaction required in the formation of leukotrienes. Leukotriene formation is essential to the inflammatory process and inhibition of them further enhances liver function.

Of particular interest to athletes, in addition to its potent protective functions, is the stimulation of protein synthesis, nucleic acid metabolism and glycogenesis.

Traditional Use

Milk thistle is the dried fruit and is described in Chinese pharmacopoeias as providing nourishment to restore liver functions and balance yin and yang. Silymarin, the active agent promotes the regeneration of injured hepatic cells. It is used in the treatment of cirrhosis, hepatitis and fatty inflammation of the liver.  Also called wild artichoke.

Chemistry

Milk Thistle contains silymarin (the collective name for a group of three flavonoid compounds, silybin, silydianin, and silychristin), which are important liver-protecting substances.

Pharmacology

Silymarin is a very powerful antioxidant and increases glutathione and superoxide dismutase concentrations in liver cells (hepatocytes).  The increase in glutathione concentration increases the capacity of the liver to detoxify drugs, hormones, and other metabolizes that it has responsibility for.

Silymarin is an inhibitor of lipoxygenase. Lipoxygenase catalyzes a reaction required in the formation of leukotrienes. Leukotriene formation is involved in the inflammatory process and its inhibition further enhances liver function.

 

Traditional use

Picrorhiza (kutki) is found in the Himalayan region and has been in use in Ayurveda for centuries as a cure for jaundice, liver disease, indigestion and related conditions.

Modern Use

Since the liver is responsible for cholesterol removal, any beneficial protective effect offered to liver cells may also result in an improved blood lipid profile.

Chemistry and Pharmacology

Picroliv is a standardized mixture of iridoid glucosides containing 4% kutkin. Kutkin, the active component is a mixture of picrosides and kutkosides.

Extracts of pivrorhiza kurroa have shown a hepatoprotective ability due to glutathione stimulation and superoxide dismutase (SOD) activity. The overall reactivity is improved through microsomal detoxification and free radical neutralization of the superoxide anion, thereby reducing the amount of lipid peroxidation products. produced. The accumulation of damaged products cause disease. Their reduction prevents it.

A reduction of triglycerides and cholesterol as well as inhibiting the inflammatory system is the purported benefits of picroliv. This occurs by minimizing the migration of white blood cells to areas of inflammation and stabilizing mast cells. The  phytonutrients contained in Picroliv act via beta-adrenergic blockade, which accounts for its anti-inflammatory activity.

Athletic use

In addition to its role in inflammation, hepatoprotection, and antioxidant activity, extracts of P. kurroa promotes the synthesis o

More in this category: « Picroliv