SAM-e (S-adenosylmethionine)
S-adenosylmethionine, pronounced like the name ‘sammy’, is a compound that is naturally produced in the body from the amino acid methionine  It was first identified in 1952 by Italian scientists and is known to be involved in many cell reactions.

SAM-e has gained a great deal of attention due to its effect on both mood and inflammation.
SAM-e has been prescribed by doctors in Europe to treat depression, arthritis and fibromylagia for over two decades. It became available in the US as a dietary supplement in 1999.

SAM-e acts as a methyl donor in cell reactions. In particular, SAM-e promotes the formation of dopamine and serotonin, two important neurotransmitters.
SAM-e is also involved in the production of glutathione, a key antioxidant needed to quench free radicals. It is sometimes combined with milk thistle as a liver restorative